Estradiol

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estradiol namely preoccupied through the peel of estrogen treatment agent. Add women with ovarian secretion of fewer than 17-β estradiol, meantime averting the side effects reasoned along spoken (chest pain, heaviness gain, hypertension, gallstones and liver dysfunction, etc.). Estrogen can induce cells to synthesize DNA, RNA and the corresponding organizations of a crowd of another proteins.

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Introduction Defining drug name: English name: Chinese Alias: English Alias: Type: Usage notes the role and use pharmacokinetic Pok harmful reactions contraindications dosage formulations Introduction Defining

estradiol (o) estradiol C18H24O2 is a steroidal estrogen. With α, β are two types, α-type mighty physiological effects. Waters such for temperature and Tanner (Wintersteiner et al.1935) have been extracted from the productive ma niu, in appending, the urine from pregnant women, people placenta, piglet ovary acquired. Male testes alternatively the urine of horses there. Because it has a lusty effect of sex hormones, so that it alternatively its ester is actually the maximum major ovarian hormone secretion. Estradiol benzoate is to determine the potency of sex hormones international unit of the found matter of which has been accepted. Drug Name: Estradiol English name: Estradiol Chinese Synonyms: 17-β estradiol, estradiol benzoate English alias: Dihydroxyoestrin, DihydroxyoestrinMonobenzoate, Oestradiol, OestroGel Category: Western women use narcotics and estradiol in vivo effectively secreted by the ovaries mature follicles, a natural estrogen, can promote and regulate the feminine sex organs and secondary sex characteristics of regular evolution. The chief pharmacological effects consist in ...: ① subserve endometrial hyperplasia; ② promote uterine synopsis; ③ promote proliferation of ductal growth, but higher doses can taboo the release of anterior pituitary prolactin, estradiol reduces milk

nectar secretion; ④ anti-androgen; ⑤ dwindle blood cholesterol, and can increase the calcium in the bones of silence. This production can be absorbed from the gastrointestinal tract and skin, but oral accessible damaged, so the main use of intramuscular and topical. When the skin penetration from topical estradiol directly into the blood rotation, avoiding 1st pass liver metabolism, without break to liver function. This production is less lively in the metabolism of estrone and estriol, and glucuronic acid and sulfuric acid with the alignment of inactivated, excreted in urine. Clinical use of ovarian insufficiency or absence of ovarian hormones caused by a kind of symptoms, mainly dysfunctional uterine bleeding, primary amenorrhea, menopausal syndrome, and prostate malignancy. Male estradiol produced in the prostate, the masculine gonads of three vice: seminal vesicles, urethra cones gland, prostate gland. Which are particularly vulnerable because of prostate smoking as reasons such as Estradiol in the prostate behind dismiss, in the adrenal into prostaglandins. Female animals in the prostate can induce abortion. Prostaglandins in masculine beasts is mainly to preserve the man secondary sexual characteristics. This production can be accustomed to back milk. Use of intramuscular injection: day 1, 4mg, once each 3 to 5 days. Note the liver and kidney dysfunction were hanged. Bogey for breast, vulvar and vaginal mucosa. [Reference scope] serum test (unit: ng / L) men: <0.2 women: follicular phase <0.3, luteal phase 1-16, 2-243 pregnancy, menopause <0.2 absorption pharmacokinetic Pok The blood and tissue fluid transfer to the target cells, plasma protein with moderate or high

estradiol

combined with tissue-specific rejoinder of estrogen receptor protein in the tissue with the formation of complex, which has multiple functions. Some of estrogen absorbed through the vaginal mucosa, likened with systemic administration Ni, which either the vagina or intestinal administration, effect can also be equal. This product is absorbed through the skin of estrogen therapy agent. Add women with ovarian secretion of less than 17-β estradiol, while avoiding the side effects caused by oral (breast pain, weight gain, hypertension, gallstones and liver dysfunction, etc.). Estrogen can induce cells to synthesize DNA, RNA and the corresponding organizations of a heap of different proteins. Mainly in the liver metabolism through the liver - can be absorbed by intestinal loops, but some parts of the metabolism of synthetic estrogen, has not been fully insistent. The kidneys in the urine. For the natural estrogen estradiol, 17β-estradiol in the maximum biological movement, deserving to oral invalid, often made of injection. Dosage and dysfunctional uterine bleeding daily intramuscular injection of 4 ~ 6mg, bleeding to the day after the narrowing 1mg, for 21 days out, plus the 14th day of estradiol injection, daily 10mg. Artificial menstrual cycle on the 5th day of bleeding daily intramuscular injection of 1

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mg, injection 16 days, the daily and 10mg intramuscular progesterone, the two drugs used simultaneously, the afterward bleeding 5 days and then reiterate the treatment, commonly required 2 to 3 cycles. Application of the minimum efficient potion, the shortest feasible time, in mandate to reduce possible adverse reactions; male and female patients after hysterectomy, ordinarily in cycles of therapy,xuqianhao.com, medication three weeks that the withdrawal a week, equivalent to the natural menstrual wheel, estrogen changes, women with a uterus, in mandate to avoid over-stimulation, in the time of the final 10 to 14 days plus progestin hormone analog Ni concentration of the natural wheel; long-term or cumbersome use of estrogen, while the withdrawal or decrement to be gradually reducing. Long-term use of estrogen are required to regularly check: blood pressure; liver function; vaginal cytology; physical exam every 6 to 12 months, 1 or prescribed; cervical cancer hindrance tarnish once a year. Topical. Postmenopausal women 1 2.5g, in the morning or nightfall with a wreck after the deposition bath. 1 to 24 month daily use. From the 13th day combined with oral progesterone preparations (such as An Qitan 100mg / day), combination therapy 12. Deactivated end of every month from 25 to 1 week, then repeat the treatment. Postmenopausal women not ashore the 6th day menstrual wheel, daily use of 2.5g, as upon method applied to the skin, once every 25, after serving 13 plus progesterone arrangements (such as An Qitan daily 100mg). This product is applied to apply the morning elbow, neck, face, abdomen or leg skin, 2min after clothing. Spreads can not be part of the breast and vagina, and do not touch mucous layers. This product is absorbed through the skin, the estradiol / estrone ratio <1, in line with physiological ratio, the effective prevention of osteoporosis. Adverse reaction 1, but not common or rare adverse reactions should be noted: ① irregular vaginal bleeding, drip

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out, breakthrough bleeding, bleeding or long-term amenorrhea; ② drowsiness; ③ prevalent urination or painful urination; ④ caustic or sudden headache; ⑤ action sudden loss of coordination, involuntary campaigns of keen (chorea); ⑥ chest, upper belly (abdomen), groin or thigh, primarily calf brawn pain, arm or leg disability or numbness; ⑦ shortness of inhalation,godbo, sudden, unexplained; ⑧ sudden language or pronunciation is unclear; ⑨ Sudden change in vision (retinal hemorrhage or blood clot); ⑩ blood pressure; ⑩ arise small breast lumps; ⑩ cerebral depression; ⑩ eye conjunctiva or yellowish discoloration of skin, disburse consideration to hepatitis or biliary prevention; ⑩ rash; ⑩ thick white curd-like vaginal discharge (candidiasis). 2, occur extra frequently, but constantly proceeded to decrease after treatment: ① abdominal cramps or flatulence; ② meager appetite; ③ nausea; ④ ankle and foot edema; ⑤ breast tenderness and (or) bulging; ⑥ weight gain or reduced. May have nausea, spewing, breast tenderness, pain, endometrial hyperplasia. This product contains alcohol elements, skin allergies, whether exposure to mucosal sites, there will be provocation. Taboo (1) Do not use during pregnancy estradiol, systemic ministry may cause fetal malformations, vaginal administration too should disburse attention. Baby girl connate to occur after treatment of reproductive tract abnormalities, rare cases have occurred in the reproductive old of vaginal cancer or cervical cancer. Estradiol via breast milk and into the discharge, and to inhibit lactation, lactation. (2) The emulating conditions ought be banned: ① understood or suspected breast cancer, for management of perfected metastatic breast cancer as one exception; ② understood or suspected estrogen-dependent tumors; ③ sensitive thrombophlebitis, or thrombosis embolism; ④ estradiol used in the quondam, he had accompanied thrombophlebitis or thromboembolic history, for the treatment of perfected breast cancer and prostate cancer exceptions; ⑤ a history of cholestatic jaundice; ⑥ not confirm the diagnosis of vaginal bleeding. (3) The following diseases of estradiol ought be used with caution: ① asthma; ② heart failure; ③ top of the epilepsy; ④ depression: ⑤ migraine; ⑥ renal dysfunction, estrogen can increase water retention; ⑦ diabetes; ⑧ benign breast ailment; ⑨ cerebrovascular ailment; ⑩ coronary aisle disease; ⑩ endometriosis; ⑩ history of gallbladder disease or cholecystectomy, particularly gallstones; ⑩ erratic liver function; ⑩ hypercalcemia, associated with tumor or metabolic bone disease; ⑩ hypertension; ⑩ pregnancy, history of jaundice or jaundice, liver damage estradiol has reminded repetition hazard Xian Xing; ⑩ keen, intermittent or complex liver of porphyria; ⑩ renal dysfunction; ⑩ thyroid disease; ⑩ uterine fibroids. Liver and kidney dysfunction maimed. Estrogen-dependent cancer, uterine cancer, breast cancer, unexplained vaginal bleeding, phlebitis, gallbladder disease, diabetes, blood clots and uterine fibroid embolization patients hanged. Preparation estradiol benzoate injection (1) 1ml: 1mg (2) 1ml: 2mg intramuscular injection, a 0.5-1.5mg, 2-3 periods a week. Average daily volume replacement therapy 0.2-0.5mg. For dysfunctional uterine bleeding, a journal intramuscular injection of 4-6mg, reduced daily or every other day after bleeding 1mg, once every 3 weeks, emulating the use of progesterone. For withdrawal of milk a day without bulging in the breast ahead the intramuscular injection of 4mg, once every 3-5 days. Gel: Each 80g (including estradiol 0.6mg / g). Open Category: Medical Pok, Pok Pharmacology, hormones and narrated drugs, sex hormones and promote the sex hormones, estrogen and synthetic drugs like me to improve the